Prof. Dr. Arwen Pearson
Group Leader
Experimental Biophysics
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Arwen is a biophysicist with a background in X-ray crystallography, single crystal spectroscopy and structural enzymology and a strong interest in the development of new methods to probe biological molecular mechanisms. She obtained a BSc(hons) in Biochemistry from the University of Bath (1997) and a PhD in structural biology from the University of St Andrews (2001), working with Garry Taylor. She then did postdoctoral work in structural enzymology in the lab of Carrie Wilmot at the University of Minnesota, working on the biogenesis of the protein derived cofactor tryptophan tryptophylquinone. In 2006 she moved back to the UK to the Astbury Centre for Structural Molecular Biology at the University of Leeds as an independent research fellow, taking up a lectureship in 2011. In 2014 she moved to the University of Hamburg to join the Hamburg Centre for Ultrafast imaging as Professor of Experimental Biophysics.
Publications
2024
Power Density Titration of Reversible Photoisomerization of a Fluorescent Protein Chromophore in the Presence of Thermally Driven Barrier Crossing Shown by Quantitative Millisecond Serial Synchrotron X-ray Crystallography
Published: Journal articles: Journal of the American Chemical Society, Vol. 146, 24, 16394-16403, 10 p.
- DOI: 10.1021/jacs.3c12883
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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin
Published: Journal articles: Communications Chemistry, Vol. 7, 1
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2022
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
Published: Journal articles: Communications Biology, Vol. 5, 1
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Structure and diffusive dynamics of aspartate α-decarboxylase (ADC) liganded with d-serine in aqueous solution
Published: Journal articles: Physical Chemistry Chemical Physics, Vol. 24, 34, 20336-20347, 12 p.
- DOI: 10.1039/D2CP02063G
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Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility
Published: Journal articles: Science Immunology, Vol. 7, 73
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Best practices for time-resolved serial synchrotron crystallography
Published: Journal articles: Acta Crystallographica Section D Structural Biology, Vol. D78, 14-29
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2021
Using photocaging for fast time-resolved structural biology studies
Published: Journal articles: Acta Crystallographica Section D Structural Biology, Vol. D77, 1218-1232
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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
Published: Journal articles: Science, Vol. 372, 6542, 642-646, 5 p.
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X-ray-Based Techniques to Study the Nano–Bio Interface
Published: Journal articles: ACS nano, Vol. 15, 3, 3754-3807, 54 p.
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Homogeneous batch micro-crystallization of proteins from ammonium sulfate
Published: Journal articles: Acta Crystallographica Section D Structural Biology, Vol. 77, Pt 2, 194-204, 11 p.
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